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KMID : 0357920140480050346
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Korean Journal of Pathology
2014 Volume.48 No. 5 p.346 ~ p.350
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Mdm2 and p53 Expression in Radiation-Induced Sarcomas of the Head and Neck: Comparison with De Novo Sarcomas
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Song Min-Jeong
Song Joon-Seon
Roh Jong-Lyel
Choi Seung-Ho
Nam Soon-Yuhl
Kim Sang-Yoon
Kim Sung-Bae
Lee Sang-Wook
Cho Kyung-Ja
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Abstract
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Background: The pathogenesis of radiation-induced sarcomas (RISs) is not well known. In RIS, TP53 mutations are frequent, but little is known about Mdm2-p53 interaction, which is a recent therapeutic target of sarcomas.
Methods: We studied the immunohistochemical expression of Mdm2 and p53 of 8 RISs. The intervals between radiation therapy and diagnosis of secondary sarcomas ranged from 3 to 17 years.
Results: Mdm2 expression was more common in de novo sarcomas than RISs (75% vs 37.5%), and p53 expression was more common in RISs than in de novo cases (75% vs 37.5%). While half of the RISs were Mdm2(?)/p53(+), none of de novo cases showed such combination; while half of de novo sarcomas were Mdm2(+)/p53(?), which are a candidate group of Mdm2 inhibitors, only 1 RIS showed such a combination. Variable immunoprofiles observed in both groups did not correlate with tumor types, except that all of 2 myxofibrosarcomas
were Mdm2(+)/p53(+).
Conclusions: In conclusion, we speculated that both radiation-induced and de novo sarcomagenesis are not due to a unique genetic mechanism. Mdm2-expression without p53 overexpression in 1 case of RIS decreases the future possibility of applying Mdm2 inhibitors on a subset of these difficult tumors.
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KEYWORD
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Cancer, radiation induced, Head and neck neoplasms, Sarcoma, Mdm2 protein, human, Tumor suppressor protein p53
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